Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



DUSP1 Gene

protein-coding   GIFtS: 63

GC05M167290
dual specificity phosphatase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PTPN10)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
dual specificity phosphatase 11 2     MKP12 3
CL1001 2 3 5     MAP kinase phosphatase 12 3
MKP-11 2 3     serine/threonine specific protein phosphatase2
PTPN102 3 5     dual specificity protein phosphatase 12
HVH11 2     VH13
Mitogen-activated protein kinase phosphatase 12 3     EC 3.1.3.163
Dual specificity protein phosphatase hVH12 3     EC 3.1.3.483
Protein-tyrosine phosphatase CL1002 3     

External Ids:    HGNC: 30641   Entrez Gene: 18432   Ensembl: ENSG000001201297   UniProtKB: P285623   

Export aliases for DUSP1 gene to outside databases

Previous GC identifers: GC05M172450 GC05M172896 GC05M172130 GC05M172176 GC05M172127


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP1:
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It
specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase
family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late
gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity,
and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of
both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by
oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to
environmental stress as well as in the negative regulation of cellular proliferation. (provided by RefSeq)

UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562
Function: Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'

Gene Wiki entry for DUSP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP1 gene promoter:
         deltaCREB   CREB   Elk-1   STAT1beta   STAT1alpha   STAT1   HSF1 (long)   GR-beta   GR-alpha   STAT3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for DUSP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DUSP1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

DUSP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP1 gene location

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M167290:  view genomic region     (about GC identifiers)

Start:
167,290,428 bp from pter
End:
167,293,538 bp from pter
Size:
3,111 bases
Orientation:
minus strand

1 alternative location:
Chr5- 172,195,093-172,198,198     
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 1  
Size: 367 amino acids; 39298 Da
Secondary accessions: Q2V508

Explore the universe of human proteins at neXtProt for DUSP1: NX_P28562 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004408.1  

    ENSEMBL proteins: 
    ENSP00000239223 ENSP00000405230 ENSP00000415019 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant DUSP1 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for DUSP1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for DUSP1 
    Novus Biologicals Proteins for DUSP1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625 soluble fraction IEA--
    GO:0005634 nucleus IEA--
    About this table

    DUSP1 for ontologies           About GeneDecksing



    Antibodies for DUSP1: 
    Millipore Mono- and Polyclonal Antibodies for the study of DUSP1
    Sigma-Aldrich Antibody Arrays and Antibodies for DUSP1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DUSP1  (MKP1)
    OriGene Antibodies: DUSP1
    GenScript Custom Superior Antibodies Services for DUSP1 
    Novus Biologicals Antibodies for DUSP1
    Browse antibodies at Epitomics

    Assays for DUSP1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DUSP1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DUSP1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DUSP1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR001763 Rhodanese-like
     IPR000387 Dual-sp/Tyr_phosphatase
     IPR014393 Dual_MAP_Kinase_Phosphatase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS

    Graphical View of Domain Structure for InterPro Entry P28562

    ProtoNet protein and cluster: P28562

    2 Blocks protein families:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562
    Function: Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Induction: By oxidative stress and heat shock
    Enzyme Numbers (IUBMB): EC 3.1.3.16  EC 3.1.3.48 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DUSP1
    Sigma-Aldrich shRNA Panels and shRNA for DUSP1
    OriGene 29mer shRNA kits in GFP-retroviral vector: DUSP1
    OriGene shRNA RFP: DUSP1
    OriGene basic RS shRNA: DUSP1
    OriGene siRNA: DUSP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DUSP1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DUSP1 
    8/14 SABiosciences Assays for microRNAs that regulate DUSP1 (see all 14):
    hsa-miR-98 hsa-let-7d hsa-miR-429 hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: DUSP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DUSP1
    OriGene untagged cDNA clones in CMV expression vector: DUSP1
    OriGene 3'-UTR clone: DUSP1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DUSP1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for DUSP1 

    Genatlas biochemistry entry for DUSP1:
    dual specificity (tyr/thr) phosphatase 1,reversing the activation of mitogen-activated protein (MAP) kinase
    family,vaccinia virus phosphatase VH1-like 1,induced by EGF,predominantly expressed in lung,placenta,pancreas,involved
    in signal transduction

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725 protein tyrosine phosphatase activity ----
    GO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS1406996
    GO:0005515 protein binding IPI16286470
    GO:0008138 protein tyrosine/serine/threonine phosphatase activity ----
    GO:0008330 protein tyrosine/threonine phosphatase activity IEA--
    About this table

    DUSP1 for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dusp1):

    cardiovascular systemhomeostasis/metabolismimmune systemlife span-post-weaning/agingrespiratory system
    skeleton

    DUSP1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    DUSP1 for pathways           About GeneDecksing

    4 Millipore Pathways for DUSP1
        Selected targets of GCR-alpha
    Development EGFR signaling pathway
    Signal transduction Erk Interactions- Inhibition of Erk
    Transcription P53 signaling pathway

    5/7 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  DUSP1 (see all 7)
        Aldosterone Signaling in Epithelial Cells
    p38 MAPK Signaling
    ERK/MAPK Signaling
    G-Protein Coupled Receptor Signaling
    RAR Activation

    1 Kegg Pathway  (Kegg details for DUSP1):
        hsa04010 MAPK signaling pathway

        SABiosciences Pathway-Focused PCR Arrays including DUSP1 (see all 6): PAHS-040A PAHS-045A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for DUSP1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP1

    5/24 Interacting proteins for DUSP1 (ENSP000002392233 P285621) via UniProtKB, MINT, and/or STRING (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284821STRING: ENSP00000215832 EBI-975493,EBI-959949
    RPS27AP0CG471EBI-975493,EBI-413034
    SKP2Q133091EBI-975493,EBI-456291
    MAPK14ENSP000002297943STRING: ENSP00000229794
    DOK1ENSP000002336683STRING: ENSP00000233668
    About this table

    5/16 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 16):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470 protein dephosphorylation IEA--
    GO:0006979 response to oxidative stress TAS1406996
    GO:0007049 cell cycle IEA--
    GO:0009416 response to light stimulus IEA--
    GO:0010033 response to organic substance ----
    About this table

    DUSP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    DUSP1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP1
    10/52 Novoseek chemical compound relationships for DUSP1 gene (see all 52)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 95.9 82 7780739 (7), 8106404 (7), 8168826 (6), 8390041 (5) (see all 27)
    triptolide 74 21 19893732 (5), 19289102 (1), 19476641 (1), 19755862 (1) (see all 9)
    pd 98,059 61.9 14 9202001 (1), 10473620 (1), 16081065 (1), 10873641 (1) (see all 12)
    sodium orthovanadate 60.7 6 11278958 (2), 15242861 (1), 7585624 (1)
    dexamethasone 57.1 78 12391149 (6), 17513787 (5), 15476200 (4), 18652821 (4) (see all 26)
    sb 203580 53.2 6 19648110 (1), 11577072 (1), 9501207 (1), 11689710 (1) (see all 5)
    tyrosine 52.8 57 18434324 (3), 7780739 (2), 17207923 (2), 8390041 (2) (see all 24)
    ag 1478 51.9 5 19175673 (2), 16081869 (1)
    vanadate 50.9 11 12529177 (2), 19893732 (2), 12186877 (1), 7700643 (1) (see all 6)
    manumycin 48.5 3 12452012 (3)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DUSP1
    Sigma-Aldrich shRNA Panels and shRNA for DUSP1
    OriGene 29mer shRNA kits in GFP-retroviral vector: DUSP1
    OriGene shRNA RFP: DUSP1
    OriGene basic RS shRNA: DUSP1
    OriGene siRNA: DUSP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DUSP1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DUSP1 
    8/14 SABiosciences Assays for microRNAs that regulate DUSP1 (see all 14):
    hsa-miR-98 hsa-let-7d hsa-miR-429 hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: DUSP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DUSP1
    OriGene untagged cDNA clones in CMV expression vector: DUSP1
    OriGene 3'-UTR Clone: DUSP1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DUSP1 
    Primers: OriGene genome-wide validated SYBR primer pairs: DUSP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DUSP1: PPH00406A

    REFSEQ mRNAs for DUSP1 gene: 

    NM_004417.3  

    Additional cDNA sequence: 

    AJ227912.1 AK298047.1 AK298658.1 AK299391.1 AK300487.1 AK304475.1 AK316321.1 BC022463.1 
    CR602951.1 CR612401.1 CR615379.1 CR625400.1 X68277.1 

    18 DOTS entries:

    DT.450715  DT.97854855  DT.101961185  DT.100878604  DT.100878597  DT.100878602  DT.95169301  DT.120864071 
    DT.120864104  DT.91667554  DT.100878599  DT.100878606  DT.95169300  DT.100878594  DT.100878596  DT.100878600 
    DT.120864086  DT.92049103 

    24/622 AceView cDNA sequences (see all 622):

    AI685606 CB268799 AA074910 AW044544 AI081949 BQ722472 AI762374 AA488364 
    BQ694319 AI497863 AW303637 AI160915 AI452473 BU684066 AA385080 AI923677 
    BM716851 BE856575 BM688487 AA374155 BF724982 AI674311 BF358306 AI274898 

    highest scoring ESTs for DUSP1:

    X68277 AA045069 AA045451 AA129573 AA310606 AA393264 AA398653 AA459716 AA468744 AA468764 

    Unigene Cluster for DUSP1:

    Dual specificity phosphatase 1
    Hs.171695  [show with all ESTs]
    Unigene Representative Sequence: NM_004417


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP1

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                          -                           
    SP2:                                                      
    SP3:                          -     -                     
    SP4:                                                      

    About this scheme

    ECgene alternative splicing isoforms for DUSP1
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000239223(uc011dez.1 uc003mbu.1 uc003mbv.1) ENST00000434080
    ENST00000457103

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    DUSP1 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching DUSP1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1005_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X68277 1.00 1.00 1.00 1
    201041_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004417 0.60 1.00 0.82 1
    201044_x_at2, 3 U133-A 1 0.91 1.00 -- -- AA530892 0.80 1.00 0.91 1
    201041_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    201044_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    DUSP1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    DUSP1 gene expression
    DUSP1 gene electronic northern expression
    DUSP1 gene sage expression
    About these images

    CGAP SAGE TAG: CTTGACATAC

    SOURCE GeneReport for Unigene cluster: Hs.171695

    Expression variation in blood from EXPOLDB for DUSP1

    UniProtKB/Swiss-Prot: DUS1_HUMAN, P28562
    Tissue specificity: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the
    heart and skeletal muscle. Lower levels found in the brain and kidney

    Primers: OriGene genome-wide validated SYBR primer pairs: DUSP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DUSP1: PPH00406A
        SABiosciences Expression via Pathway-Focused PCR Arrays including DUSP1 (see all 6): PAHS-040A PAHS-045A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for DUSP1 gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    DUSP11   -- dual specificity phosphatase 1 93.91(n)
    98.09(a)
    489117  XM_546235.2  XP_546235.2 
    chimpanzee
    (Pan troglodytes)
    DUSP11   -- dual specificity phosphatase 1 99.64(n)
    100(a)
    471742  XM_001153609.1  XP_001153609.1 
    cow
    (Bos taurus)
    DUSP11   -- dual specificity phosphatase 1 92.73(n)
    96.73(a)
    539175  NM_001046452.1  NP_001039917.1 
    rat
    (Rattus norvegicus)
    Dusp11   -- dual specificity phosphatase 1 88.92(n)
    96.19(a)
    114856  NM_053769.2  NP_446221.1 
    mouse
    (Mus musculus)
    Dusp11 , 5 17 (13.28 cM)5
    dual specificity phosphatase 11, 5 90.1(n)1
    96.46(a)1
    192521  NM_013642.11  NP_038670.11 
     AI3259175  AK1459035  (see all 21)
    About this table        Species with no ortholog for DUSP1

    ENSEMBL Gene Tree for DUSP1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for DUSP1 gene
    DUSP42  DUSP22  DUSP52  

    DUSP1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/87 NCBI SNPs in DUSP1 are shown (see all 87)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs123941,2
    C172195319(-) TTTTTG/TTTTTT 2 -- ut310--------
    rs3223511,2
    C,F,A,172194873(+) ATGGGC/TAGACA 1 -- ng3116Minor allele frequency- T:0.26NS EA NA WA 2034
    rs3223791,2
    C,A,H,172200189(-) ctcagC/Gctctc 1 -- ng5110Minor allele frequency- G:0.00NS EA NA WA 432
    rs3223801,2
    C,F,A,172199592(-) ACGACG/ACAGGG 1 -- ng5117Minor allele frequency- A:0.23MN NA EA NS WA 861
    rs3223811,2
    C,F,172199489(-) GTACCT/CAGCGC 1 -- ng5112Minor allele frequency- C:0.09NS NA WA 250
    rs3223821,2
    C,F,A,172198952(+) TGCCAC/TGAAAG 1 -- ng51 tfbs322Minor allele frequency- T:0.18MN NS EA NA WA 3354
    rs8811501,2
    C,F,O,A,H,172198905(+) CCTGTT/ATCCCA 1 -- ng5119Minor allele frequency- A:0.18MN NS EA NA WA 2607
    rs8811521,2
    C,F,172198555(+) AGAACG/AGGCGA 1 -- ng5112Minor allele frequency- A:0.19MN EA NS NA WA 3288
    rs8811531,2
    C,F,172199747(-) CAAATG/AAAGGT 1 -- ng515Minor allele frequency- A:0.02NA EA MN WA 474
    rs10589471,2
    C172195264(-) TCAGCA/CCTGAT 2 -- ut310--------
    About this table

    HapMap Linkage Disequilibrium images for DUSP1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DUSP1
         1 CNV: 2608

    QIAGEN SeqTarget long-range PCR primers for resequencing DUSP1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DUSP1 for disorders           About GeneDecksing

    OMIM: 600714

    10/28 Novoseek disease relationships for DUSP1 gene (see all 28)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 32.5 12 15640643 (3), 15569826 (1), 18495502 (1), 18508759 (1) (see all 8)
    tumors 29.7 49 8909245 (4), 15640643 (3), 12432554 (3), 9010448 (2) (see all 24)
    shock 27.1 17 15640643 (4), 12748284 (2), 15677475 (1), 7780739 (1) (see all 10)
    prostatic intraepithelial neoplasia 17.6 2 9645439 (1)
    hypertrophy 16.7 1 15313208 (1)
    ovarian cancer 16 4 18089824 (2), 19755862 (1), 19697705 (1)
    breast cancer 14.9 24 19417026 (6), 20111893 (2), 17483361 (2), 14695202 (2) (see all 9)
    cancer 13.4 14 18922965 (3), 15243131 (2), 15856297 (1), 11710837 (1) (see all 9)
    breast carcinoma 11.2 4 19417026 (1), 15448190 (1), 8909245 (1), 17483361 (1)
    inflammation 4.66 6 16387640 (2), 18922786 (1), 20043958 (1), 16317391 (1)
    About this table

    Genetic Association Database (GAD): DUSP1
    Human Genome Epidemiology (HuGE) Navigator: DUSP1 (10 documents)

    Export disorders and mutations for DUSP1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/347 PubMed articles for DUSP1 gene, integrated from 7 sources (see all 347):
    (articles sorted by number of sources associating them with DUSP1)
    1. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. (PubMed id 1406996)1, 2, 3 Keyes S.M. and Emslie E.A. (1992)
    2. Isolation and characterization of a human dual specificity protein- tyrosine phosphatase gene. (PubMed id 8106404)1, 2, 7 Kwak S.P.... Dixon J.E. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Association of homozygous deletion of the Humhv3005 and the VH3-30.3 genes with renal involvement in systemic lupus erythematosus. (PubMed id 12765304)1, 4 Cho M.L....Cho C.S. (2003)
    5. Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. (PubMed id 7806236)1, 3 Martell K.J....Trent J.M. (1994)
    6. Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. (PubMed id 12432554)1, 7 Denkert C....Hauptmann S. (2002)
    7. VEGF and thrombin induce MKP-1 through distinct signaling pathways: role for MKP-1 in endothelial cell migration. (PubMed id 18003751)1, 7 Kinney C.M....DiCorleto P.E. (2008)
    8. Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin. (PubMed id 19417026)1, 7 Rojo F....Albanell J. (2009)
    9. KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. (PubMed id 19411256)1, 7 Liu R....Chen C. (2009)
    10. ERK-dependent MKP-1-mediated cisplatin resistance in human ovarian cancer cells. (PubMed id 18089824)1, 7 Wang J....Wu G.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1843 HGNC: 3064 AceView: DUSP1 Ensembl:ENSG00000120129 euGenes: HUgn1843
    ECgene: DUSP1 Kegg: 1843 H-InvDB: DUSP1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for DUSP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/dusp1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for DUSP1 gene:
    Search GeneIP for patents involving DUSP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for DUSP1 Antibodies for DUSP1
     Super-pooled esiRNAs for DUSP1 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for DUSP1 Browse microRNA Mimics at Sigma-Aldrich
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DUSP1
     SeqTarget long-range PCR primers for resequencing DUSP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DUSP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DUSP1
     GenScript Custom Purified and Recombinant Proteins Services for DUSP1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for DUSP1
     GenScript Custom Assay Services for DUSP1 GenScript Custom Superior Antibodies Services for DUSP1
     GenScript Custom overexpressing Cell Line Services for DUSP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for DUSP1  (MKP1)

     Regulatory tfbs in DUSP1 promoter
     Search Chromatin IP Primers for DUSP1
     RT2 qPCR Primer Assay for DUSP1
     GNC Network for DUSP1
     Assays for microRNAs that regulate DUSP1
     SABiosciences PCR Arrays including DUSP1
     Search Tocris compounds for DUSP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for DUSP1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for DUSP1
     Proteins for DUSP1
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for DUSP1
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    DUSP1 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4